As I sliced into the golden-brown crust of this Easy Southern Meatloaf, memories of family dinners instantly flooded back. With just five simple ingredients, this recipe not only delivers a juicy, satisfying meal but also brings that cozy sense of home into your kitchen. This classic comfort food is truly a crowd-pleaser, perfect for busy weeknights when you crave something hearty yet uncomplicated. The sweet, tangy ketchup glaze ties everything together, making it a delightful centerpiece for any dinner table. Whether served alongside velvety mashed potatoes or crisp green beans, this dish promises to warm both your belly and your heart. Are you ready to create a new family favorite?

Why is Southern Meatloaf So Comforting?
Simplicity: This recipe is a breeze, requiring just five everyday ingredients that you likely already have in your pantry.
Nostalgic Flavor: With a ketchup glaze that brings sweetness and tang, each bite tastes like childhood memories around the dinner table.
Versatile Option: Feel free to customize by adding chopped veggies or swapping bread types, adapting it to your family’s taste.
Crowd-Pleasing Meal: Perfect for any occasion, this meatloaf is sure to please kids and adults alike, making it an ideal dish for gatherings!
Make-Ahead Friendly: Prep in advance and freeze for effortless convenience, ensuring a quick, satisfying dinner is always within reach.
Southern Meatloaf Ingredients
For the Meatloaf
• Ground Hamburger – This is your main protein source, providing a delicious, hearty structure; leaner options may reduce flavor slightly.
• Egg – Acts as a binder for the meatloaf, keeping it tender and cohesive during cooking; make sure to beat it well before adding.
• Salt & Pepper – Key seasonings that enhance the overall flavor; adjust to suit your taste preferences.
• Breadcrumbs – Offers structure and moisture retention; a heaping tablespoon is recommended; can easily substitute with crushed saltine crackers or torn bread if desired.
• Onion – A vital ingredient for adding sweetness and moisture; use one small or half a medium onion, finely chopped.
For the Glaze
• Ketchup – Adds a sweet and tangy flavor to the meatloaf, as well as serving as a delicious glaze; about ½ cup is suggested, with the option to baste during the last few minutes of baking.
This Southern meatloaf is not just a meal; it’s an experience wrapped in nostalgia that brings family members together around the dinner table!
Step‑by‑Step Instructions for Southern Meatloaf
Step 1: Preheat the oven
Begin by preheating your oven to 350°F (175°C). This ensures a perfectly baked southern meatloaf, developing that inviting golden-brown crust. While the oven warms up, gather your mixing bowl and a loaf pan, preparing them for the delicious assembly of ingredients that’s about to follow.
Step 2: Combine the meat and egg
In a spacious mixing bowl, add the ground hamburger along with the beaten egg. Using your hands or a sturdy fork, combine these ingredients thoroughly until they are evenly mixed, creating a cohesive blend. The egg acts as a binder, ensuring your southern meatloaf holds its shape beautifully as it cooks.
Step 3: Incorporate breadcrumbs and onion
Next, mix in a heaping tablespoon of breadcrumbs and the finely chopped onion into the meat mixture. Stir until all components are well incorporated; this step enhances the moisture and flavor profile of your meatloaf, making it irresistible. You’ll want to feel the texture become slightly denser as everything comes together.
Step 4: Add ketchup
Pour approximately ½ cup of ketchup into the blending bowl, ensuring even distribution throughout the mixture. This pivotal step infuses the meatloaf with a sweet and tangy flavor that defines traditional southern meatloaf. Mix everything well, ensuring the ketchup is clouding the other ingredients in a vibrant red hue.
Step 5: Shape the meatloaf
Carefully transfer your meat mixture into the prepared loaf pan, pressing it down gently to shape it evenly. Ensure that the surface is smooth and level; this will help your southern meatloaf cook uniformly. With the mixture placed in the pan, you’ll begin to see the comforting creation come to life.
Step 6: Bake the meatloaf
Place the loaf pan in the preheated oven on the center rack. Bake for approximately 1 hour to 1 hour and 15 minutes. Keep an eye on it; the meatloaf should develop a beautiful brown crust and firm up. Every 30 minutes, carefully pour off any excess grease to ensure a delicious, juicy meatloaf without being overly oily.
Step 7: Baste for flavor
Optional but highly recommended: during the last 15 minutes of the baking time, baste the top of the meatloaf with additional ketchup. This not only enhances the flavor but gives it an extra layer of glossy texture that makes your southern meatloaf utterly appetizing.
Step 8: Check for doneness
When the baking time elapses, check for doneness. The internal temperature should read 160°F (71°C) when tested with a meat thermometer. If it isn’t quite there, return it to the oven for a few more minutes. You’re looking for a firm center and a lovely brown crust turning crispy at the edges.
Step 9: Rest and serve
Once perfectly baked, remove the meatloaf from the oven and let it rest for about 10 minutes. This resting time allows the juices to settle, resulting in a tender southern meatloaf. Slice and serve it warm alongside your favorite sides, like creamy mashed potatoes or crisp green beans, for a comforting, nostalgic meal.

Southern Meatloaf Variations to Delight
Feel free to customize your southern meatloaf for a delightful twist that suits your taste buds and dietary needs!
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Gluten-Free: Substitute breadcrumbs with gluten-free panko or crushed cornflakes for an equally tasty result.
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Vegetarian: Use lentils or black beans in place of ground hamburger, adding breadcrumbs and spices for flavor.
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Spicy Kick: Incorporate chopped jalapeños or a splash of hot sauce into the meat mixture for a mouthwatering heat.
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Herb Infusion: Add fresh herbs like parsley or thyme for an aromatic layer, truly elevating your comfort dish.
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Cheesy Addition: Mix in a handful of shredded cheese, like cheddar or mozzarella, before baking for a melty, delicious surprise.
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Savory Veggie Boost: Throw in chopped green peppers, carrots, or mushrooms for extra flavor and nutrition in each bite.
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Flavorful Topping: Instead of plain ketchup, try a mixture of barbecue sauce and honey for a sweet, smoky glaze.
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Mini Meatloafs: Shape into meatballs or mini-loaves for quick baking and individual portions—perfect for family meals or freezing!
These variations keep the essence of your beloved southern meatloaf while inviting creativity into your kitchen. For more inspiration, check out my Comforting Meatloaf Tips or explore how to make classic Mashed Potatoes to accompany your meal!
How to Store and Freeze Southern Meatloaf
Fridge: Store leftover southern meatloaf in an airtight container in the refrigerator for up to 3 days, ensuring it stays moist and flavorful.
Freezer: For longer storage, freeze cooked meatloaf slices wrapped tightly in plastic wrap and foil for up to 3 months. This makes meal planning a breeze!
Reheating: When ready to enjoy, thaw in the fridge overnight and reheat in the oven at 350°F (175°C) for about 20 minutes, or until heated through.
Serving Tip: Serve reheated slices with a fresh drizzle of ketchup on top to revitalize the flavors and bring that comforting touch back!
Expert Tips for Southern Meatloaf
Mix by Hand: Use your hands for mixing the ingredients; this ensures a better texture and flavor integration in your southern meatloaf.
Consistency is Key: Ensure the mixture is not too dry or too wet; it should hold together but not be overly sticky to maintain its shape while cooking.
Keep Grease at Bay: Pour off excess grease every 30 minutes while baking to avoid a greasy texture, allowing your meatloaf to remain juicy but not oily.
Use a Meat Thermometer: For perfect doneness, use a meat thermometer to check that the internal temperature reaches 160°F (71°C); this prevents undercooking or overcooking.
Customize it: Feel free to add veggies like green peppers or swap breadcrumbs for crushed saltines; this allows you to put your twist on a classic southern meatloaf!
What to Serve with Easy Southern Meatloaf
Pairing this delightful meatloaf with the right sides creates a comforting dinner experience that warms both heart and home.
- Creamy Mashed Potatoes: Their velvety texture complements the meatloaf’s juicy bite while soaking up all those delicious flavors.
- Crisp Green Beans: Fresh and crunchy, they add a vibrant contrast, enhancing the wholesome essence of your meal.
- Roasted Vegetables: A mix of carrots, bell peppers, and zucchini brings earthy flavors, adding colorful variety to the dinner plate.
- Cornbread Muffins: Soft and slightly sweet, cornbread muffins make a perfect pairing, adding a Southern touch to the experience.
- Coleslaw: This refreshing side introduces a tangy crunch, balancing the rich flavors of the meatloaf beautifully.
- Sweet Potato Fries: Their natural sweetness offers a delightful contrast and introduces a fun, crispy texture.
- Baked Mac and Cheese: An indulgent pairing that adds creaminess and comfort, making your dinner truly unforgettable.
- Iced Tea or Lemonade: The quintessential Southern drinks that provide a refreshing counterpoint to the savory meatloaf.
- Apple Pie: End the meal on a sweet note with this classic dessert that evokes warmth and nostalgia with each bite.
Make Ahead Options
These Easy Southern Meatloaf preparations are a game-changer for busy cooks looking to save time! You can shape the meatloaf and wrap it tightly in plastic wrap and foil, storing it in the freezer for up to 3 months. To maintain quality, it’s important to ensure it’s well wrapped to prevent freezer burn. When you’re ready to enjoy, simply bake it straight from frozen at 350°F (175°C) for about 1 hour and 30 minutes, or until it reaches an internal temperature of 160°F (71°C). If you’re planning to make it up to 24 hours in advance, feel free to mix all the ingredients and refrigerate the unbaked meatloaf in the loaf pan. When ready, just pop it in the oven and you’ll have delicious southern meatloaf with minimal effort!

Southern Meatloaf with Ketchup Glaze Recipe FAQs
What type of ground meat is best for Southern meatloaf?
Absolutely! While ground hamburger is the traditional choice, you can use lean ground beef or even turkey for a healthier option. However, keep in mind that leaner meats may slightly reduce the overall flavor, so it’s all about balancing health with taste!
How should I store leftover Southern meatloaf?
To keep your leftover southern meatloaf moist and tasty, store it in an airtight container in the refrigerator for up to 3 days. I recommend reheating individual slices in the oven at 350°F for about 20 minutes, which helps maintain the juicy texture rather than a microwave, which could make it dry.
Can I freeze cooked Southern meatloaf?
Yes! For longer storage, wrap the cooked meatloaf slices tightly in plastic wrap and then foil, labeling them with the date. You can freeze it for up to 3 months. When you’re ready to enjoy, simply thaw in the refrigerator overnight, then reheat in the oven at 350°F for about 20 minutes until heated through.
What should I do if my meatloaf is too dry?
If you find your southern meatloaf turning out dry, it could be due to overbaking or using too lean of a meat. Next time, be sure to check for doneness with a meat thermometer and bake until it reaches 160°F. Additionally, you might consider adding a touch more egg or breadcrumbs for moisture, or try drizzling a bit of broth over the meatloaf before baking for enhanced juiciness!
Are there any dietary considerations for making Southern meatloaf?
Certainly! If you’re catering to dietary restrictions, you can substitute breadcrumbs with gluten-free options like crushed rice crackers or oats. Also, if someone has an egg allergy, you can use a flaxseed meal mixed with water (1 tablespoon flaxseed meal with 2.5 tablespoons water) as a binding agent instead of an egg. This will help create a cohesive meat mixture while accommodating different needs.
What’s the best way to tell if my Southern meatloaf is done?
To ensure your southern meatloaf is perfectly cooked, the best method is to use a meat thermometer. Insert it into the center of the loaf; it should read 160°F (71°C) to be fully cooked. If you don’t have one, look for a firm center with no signs of pink—this way, you’ll enjoy a beautifully tender and safe-to-eat dish!

Southern Meatloaf with Ketchup Glaze: Comfort on a Plate
Ingredients
Equipment
Method
- Preheat your oven to 350°F (175°C).
- In a mixing bowl, add the ground hamburger and beaten egg, mixing thoroughly.
- Incorporate breadcrumbs and chopped onion into the meat mixture.
- Pour in the ketchup and mix until evenly distributed.
- Transfer the mixture into a loaf pan, pressing down gently.
- Bake in the preheated oven for 1 hour to 1 hour and 15 minutes.
- Baste with ketchup during the last 15 minutes of baking.
- Check the internal temperature; it should reach 160°F (71°C).
- Let the meatloaf rest for about 10 minutes before serving.

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